Advantan, ointment

Analogs

  • Analogue based methylprednisolone - Comfoderm.

advantan Ointments and creams based on other corticosteroids, similar in effect:

(Read the instructions before choosing a drug. Most analogues are not suitable for children and have more serious side effects)

Price

536 р. Average price online * 536 p. (tube 15g)

Where can one buy:

Instructions for use

Cream, oily and regular ointment “Ointment” and “Fat ointment” are produced, and of course cream. Oily ointment is distinguished by a large amount of wax and various paraffins, it is thicker and longer absorbed (see composition ). The cream is made on the basis of water with a small amount of fat, it is absorbed the fastest and is recommended in the acute phase.

Indications for use

This ointment is prescribed for diseases of the skin of a different nature in both adults and children (age limit up to 4 months). These diseases include:

Dosage and administration

Tube A small amount of ointment should be applied with a very thin layer in a circular motion directly on the problem areas of the skin, 1 time per day.

The course of treatment is no more than 4 weeks in children and no more than 12 weeks in adults.

Oily ointment due to its high fat content is well suited for dry skin.

If soak on the skin is not, then the usual ointment is more suitable.

Contraindications

xl20382 If any viral diseases appear in the area of ​​applying the ointment (for example, smallpox, lichen, some herpes, etc.), as well as skin manifestations of syphilis and tuberculosis, then the ointment cannot be used.

This also applies to the presence of such manifestations as rosacea, oral dermatitis and reactions from vaccination.

Cream and ointment are contraindicated in children up to 4 months, people with individual intolerance to any component of the ointment.

Pregnant and lactating ointment is not contraindicated, but it should be used when absolutely necessary and after consulting a doctor.

Side effects

56041241342 Adverse reactions can occur with the use of Advantant, but extremely rarely, since the ointment is generally well tolerated. Only if the method of application is not followed (if you use the ointment for more than the prescribed time and / or apply it on a large part of the body surface) some changes in the skin can occur:

  • telangiectasia (persistent dilation of small vessels of the skin);
  • skin atrophy (irreversible change associated with a decrease in volume);
  • striae (type of skin atrophy in the form of stretch marks);
  • Acneform skin changes;
  • systemic effects due to corticosteroid adsorption.

When complying with all the norms of using the ointment, these side effects were not observed.

Sometimes (less than in 0.01% of cases) local skin reactions such as burning, itching, erythema, rash occur. In 0.01-0.1% of cases there are allergic reactions, folliculitis, hypertrichosis, oral dermatitis, skin depigmentation.

Composition and pharmacokinetics

This ointment is normal and oily - the difference in the composition of the components and their quantitative ratio.

The quantitative composition of the ointment (1 g) Ointment 0.1% (white or yellowish, homogeneous, opaque) Ointment (fat) 0.1% (white or yellowish, translucent)
Methylprednisolone aceponate 1 mg 1 mg
Paraffin white soft 350 mg 425 mg
Paraffin liquid 239 mg 394 mg
White beeswax 40 mg not contained
Microcrystalline wax not contained 150 mg
Emulsifier Dehimuls E 70 mg not contained
Castor Oil Hydrogenated not contained 30 mg
Purified water 300 mg not contained

Advantan ointment is produced in different volumes - from 5 to 50 grams.

Ointment suction

The absorption of the ointment depends on the condition of the skin and the method of application, as it can be applied with or without an occlusive dressing . Both types of ointment are absorbed rather quickly - in both children and adults, percutaneous absorption is no more than 2.5% with neurodermatitis and psoriasis (in healthy people, no more than 0.5-1.5%).

Chemical processes in the body

Old school In the epidermis and dermis, the main active ingredient in ointment methylprednisolone aceponate reacts with water. The main metabolite is the substance 6α-methylprednisolone-17-propionate. It has a high activity and high affinity for corticoid receptors of the skin, which indicates the presence of its bioactivation in the skin. In the blood, a fast connection of this metabolite with glucuronic acid occurs (conjugation process), after which it loses its activity.

All metabolites of methylprednisolone acepononate in the body do not accumulate - they are excreted from the body by the kidneys in about 16 hours.

Other

Dispensed without a prescription, stored at a temperature not exceeding 25 ° C. Shelf life of ointment and cream - 3 years, oily ointment - 5 years.

Reviews

(Leave your feedback in the comments)

The effect of ointment does not keep you waiting. It took only 3 days to get rid of contact dermatitis. Irina, Moscow

My child often has allergic rashes on the skin. The doctor prescribed Advantan ointment. I try to smear as little as possible, and the layer is thinner, but the effect does not diminish - the rash passes quickly and for a long time. Alika, Krasnodar

I have psoriasis for many years, which is aggravated by nerves. Then Advantan ointment comes to the rescue. After using the course for a long time I forget about the problem. Sergey, Astrakhan

* - The average value among several sellers at the time of monitoring is not a public offer.

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