- Analogue based methylprednisolone - Comfoderm.
Ointments and creams based on other corticosteroids, similar in effect:
(Read the instructions before choosing a drug. Most analogues are not suitable for children and have more serious side effects)
- Belogent ;
- Beloderm ;
- Hydrocortisone ;
- Lokoid ;
- Lorinden C ;
- Sinaflan ;
- Flucinar ;
- Fluorocort ;
- Elok ;
- list with a brief description on one page .
536 р. Average price online * 536 p. (tube 15g)
Where can one buy:
Instructions for use
“Ointment” and “Fat ointment” are produced, and of course cream. Oily ointment is distinguished by a large amount of wax and various paraffins, it is thicker and longer absorbed (see composition ). The cream is made on the basis of water with a small amount of fat, it is absorbed the fastest and is recommended in the acute phase.
Indications for use
This ointment is prescribed for diseases of the skin of a different nature in both adults and children (age limit up to 4 months). These diseases include:
- neurodermatitis (chronic skin disease of the neurogenic-allergic type);
- allergic , sun, contact and atopic dermatitis ;
- various types of eczema (microbial, true, dishydrotic, degenerative, etc.).
Dosage and administration
A small amount of ointment should be applied with a very thin layer in a circular motion directly on the problem areas of the skin, 1 time per day.
The course of treatment is no more than 4 weeks in children and no more than 12 weeks in adults.
Oily ointment due to its high fat content is well suited for dry skin.
If soak on the skin is not, then the usual ointment is more suitable.
If any viral diseases appear in the area of applying the ointment (for example, smallpox, lichen, some herpes, etc.), as well as skin manifestations of syphilis and tuberculosis, then the ointment cannot be used.
This also applies to the presence of such manifestations as rosacea, oral dermatitis and reactions from vaccination.
Cream and ointment are contraindicated in children up to 4 months, people with individual intolerance to any component of the ointment.
Pregnant and lactating ointment is not contraindicated, but it should be used when absolutely necessary and after consulting a doctor.
Adverse reactions can occur with the use of Advantant, but extremely rarely, since the ointment is generally well tolerated. Only if the method of application is not followed (if you use the ointment for more than the prescribed time and / or apply it on a large part of the body surface) some changes in the skin can occur:
- telangiectasia (persistent dilation of small vessels of the skin);
- skin atrophy (irreversible change associated with a decrease in volume);
- striae (type of skin atrophy in the form of stretch marks);
- Acneform skin changes;
- systemic effects due to corticosteroid adsorption.
When complying with all the norms of using the ointment, these side effects were not observed.
Sometimes (less than in 0.01% of cases) local skin reactions such as burning, itching, erythema, rash occur. In 0.01-0.1% of cases there are allergic reactions, folliculitis, hypertrichosis, oral dermatitis, skin depigmentation.
Composition and pharmacokinetics
This ointment is normal and oily - the difference in the composition of the components and their quantitative ratio.
|The quantitative composition of the ointment (1 g)||Ointment 0.1% (white or yellowish, homogeneous, opaque)||Ointment (fat) 0.1% (white or yellowish, translucent)|
|Methylprednisolone aceponate||1 mg||1 mg|
|Paraffin white soft||350 mg||425 mg|
|Paraffin liquid||239 mg||394 mg|
|White beeswax||40 mg||not contained|
|Microcrystalline wax||not contained||150 mg|
|Emulsifier Dehimuls E||70 mg||not contained|
|Castor Oil Hydrogenated||not contained||30 mg|
|Purified water||300 mg||not contained|
Advantan ointment is produced in different volumes - from 5 to 50 grams.
The absorption of the ointment depends on the condition of the skin and the method of application, as it can be applied with or without an occlusive dressing . Both types of ointment are absorbed rather quickly - in both children and adults, percutaneous absorption is no more than 2.5% with neurodermatitis and psoriasis (in healthy people, no more than 0.5-1.5%).
Chemical processes in the body
In the epidermis and dermis, the main active ingredient in ointment methylprednisolone aceponate reacts with water. The main metabolite is the substance 6α-methylprednisolone-17-propionate. It has a high activity and high affinity for corticoid receptors of the skin, which indicates the presence of its bioactivation in the skin. In the blood, a fast connection of this metabolite with glucuronic acid occurs (conjugation process), after which it loses its activity.
All metabolites of methylprednisolone acepononate in the body do not accumulate - they are excreted from the body by the kidneys in about 16 hours.
Dispensed without a prescription, stored at a temperature not exceeding 25 ° C. Shelf life of ointment and cream - 3 years, oily ointment - 5 years.
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* - The average value among several sellers at the time of monitoring is not a public offer.