Erythromycin is from different manufacturers, it is inexpensive, there are no analogues.
Other dosage forms: ointment .
: 95 р. Average online price * : 95 r.
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Instructions for use
Indications for use
The drug is prescribed in the treatment of diseases associated with bacterial pathogens:
- prevention and treatment of diphtheria and whooping cough
- legionnaires disease
- amebic dysentery
- infected wounds, burns
- scarlet fever
- primary syphilis
- pneumonia and conjunctivitis in children
- urinary infections
- bronchitis, tracheitis
- preoperative preparation of the intestine, in order to avoid possible complications.
Dosage and administration
Inside, on an empty stomach 1-1.5 hours before meals or 2 hours after. For adults, 0.25-0.5 g 4-6 times a day, depending on the state of health and the cause of the disease.
The maximum single dose of 0.5 g, the daily dose of 2 g. Erythromycin should be taken within 2-3 days after the symptoms disappear.
The dosage of the drug is largely determined by the patient's age:
- children 1-3 years old - 100 mg 4 times a day
- children 3-6 years old - 125 mg 4 times a day
- children 6-8 years old - 150-175 mg 4 times a day
- children 8-12 years old - 175-250 mg 4 times a day
- adults - 250-500 mg 4 times a day.
Dosages can be adjusted at the discretion of the doctor, with serious diseases, the dose can be increased to 4 g per day.
- Individual intolerance
- Prohibited sharing with terfenadine and astemizole (leading to cardiac arrhythmias with the risk of its complete stop)
- During pregnancy and lactation, the drug is prohibited. Due to the high penetrating power of the antibiotic, it easily penetrates the placenta and reaches the fetus. Doses of the drug, optimal for the mother's body, have a detrimental effect on the child, since his body is not able to effectively neutralize the antibiotic.
The drug penetrates into breast milk as easily, therefore, it is prescribed, as a rule, only if there is a special risk to the mother’s life and if breastfeeding is interrupted. The timing of such an interruption should be agreed with the doctor.
- Renal or hepatic failure. The deterioration of the functions of these organs leads to an increase in the period of elimination of the drug from the body.
- Combination with alcohol and drugs that increase the load on the liver: the use of antihistamines and indirect anticoagulants is undesirable.
- Hormonal contraceptives, due to a sharp decrease in their effectiveness.
Prolonged use of erythromycin can affect the functioning of the liver, up to and including liver failure. In some cases, hearing is reduced.
In order to avoid consequences, it is necessary to periodically conduct a clinical analysis of blood, ECG.
- hearing loss (reversible, hearing returns after taking the drug)
- noise in ears
- nausea, vomiting, diarrhea, dysbacteriosis, deterioration of the liver (jaundice), pancreatitis, tenesmus, candidiasis
- bitterness in the mouth for 2-3 days of use (antibiotic penetrates into all tissues, including the salivary glands)
- tachycardia (rare)
- urticaria, rash
- eosinophilia, agranulocytosis
- dizziness, nightmares
- formation of resistance of microorganisms to this antibiotic.
Composition and pharmacokinetics
1 enteric coated tablet contains:
- Erythromycin 200 mg
- Rice starch 15.5 mg; potato starch 53.3 mg; sodium carboxymethyl starch 4 mg; gelatin 14 mg; polysorbate 80 1.7 mg; talc 4 mg; magnesium stearate 7.5 mg.
Erythromycin is an antibiotic group (the least toxic antibiotics, the effect of which is directed mainly on gram-positive bacteria: staphylococci and streptococci, as well as on other pathogenic pathogens: mycoplasmas, chlamydia, legionella). Not able to affect salmonella and Koch's wand.
The principle of action of erythromycin is based on the termination of the synthesis of bacterial proteins, which can significantly reduce the speed of their reproduction and distribution in the body, but does not completely destroy them.
Erythromycin is very sensitive to food, the presence of food reduces its bioavailability. However, for tablets coated with a special enteric coating, this does not really matter - their effect is achieved already 2 hours after ingestion.
The drug is unevenly distributed in the body. By binding to plasma proteins (the number of which may increase after a meal), erythromycin is concentrated in the kidneys, liver, spleen.
Like other antibiotics of its group, erythromycin easily penetrates into all tissues, including through the placenta, and up to 50% of the plasma concentration in breast milk.
The antibiotic very poorly penetrates the meninges, which eliminates its significant impact on the brain. However, with inflammatory reactions in the lining of the brain, the permeability to the drug may increase.
The antibiotic is excreted mainly from the bile (20-30%) after its processing in the liver (90%), as well as with urine (2-5%).
Prescription. Shelf life 3 years. Store in a well-closed container, out of the reach of children.
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* - The average value among several sellers at the time of monitoring is not a public offer.