Ketoconazole is also available in other dosage forms:
- Cream ,
- Candles ,
- There are many shampoos based on ketoconazole .
Analogues
Price
: 132 р. The average price online * : 132 p.
Where can I buy:
Instructions for use
White round tablets are available, as a rule, in blisters of 10 pcs. And carton. One tablet contains 200 mg of ketoconazole.
Take once a day with meals. Adults 1-2 tablets (total from 200 to 400 mg), children poltabletki (100 mg). The decisive factor is the body weight. Children's dosage is prescribed at a weight of 15 to 30 kg, over 30 - the dosage is the same as for an adult. For children weighing less than 15 kg, 4-8 mg per kilogram of body weight per day is prescribed.
Children under 3 years old are contraindicated.
If a child weighs eg 13 kg, then its minimum dosage is 4 * 13 = 52 mg, the maximum is 8 * 13 = 80 mg. Dosage of the substance with an accuracy of milligrams at home is very difficult, however, you should try to divide the tablet into 2 equal parts, a suitable dosage of 100 mg will be obtained.
Fortunately, the drug is prescription and you can not buy it in a pharmacy.
To improve absorption, it is recommended to drink the drug with acidic drinks.
The duration of treatment is determined only by the doctor. The drug is usually prescribed against systemic mycoses and almost always additional research is needed to determine the pathogenic microflora in the body.
Indications
blastomycosis, - Coccidioidomycosis,
- Histoplasmosis,
- Chromomycosis,
- Paracoccidioidomycosis,
- Effective against various types of candidiasis , including the usual female thrush , male balanoposthitis , but is appointed extremely rarely because of the large number of pobochek.
Contraindications
- Hypersensitivity to ketoconazole,
- Liver disease,
- pregnancy,
- lactation,
- Age up to 3 years;
Prohibited taking together with the following drugs:
- Astemizole,
- Beprideil,
- Halofantrine,
- Dihydroergotamine,
- Disopyramide,
- Domperidone,
- Dofetilide,
- Dronedarone,
- Ivabradine,
- Irinotecan,
- Levacetylmetadol,
- Lercanidipine,
- Lovastatin,
- Lurasidone,
- Methadone,
- Methylergometrine,
- Midazolam (orally),
- Misolastine,
- Nisoldipine,
- Pimozide,
- Ranolazine,
- Sertindole,
- Simvastatin,
- Terfenadine,
- Triazolam,
- Felodipine,
- Quinidine,
- Cisapride,
- Everolimus,
- Eplerenone,
- Ergometrine,
- Ergotamine.
special instructions
Before the beginning of treatment it is necessary to evaluate the function of the liver to eliminate acute or chronic diseases.
Ketoconazole poorly penetrates the hemato-encephalic barrier, therefore it is inappropriate to use it in fungal meningitis.
Tablets are prescribed no earlier than 2 weeks after the abolition of glucocorticosteroids, if they were used.
Side effects
There are a lot of side effects in ketoconazole, so we remind you again, this drug should be used in the form of tablets only according to the doctor's prescription .
- headache,
- Dizziness,
- Itching, rash, hives, dermatitis , erythema, alopecia,
- A violation of the liver, toxic hepatitis and cirrhosis are not excluded,
- Nosebleeds,
- Drowsiness or vice versa, increased excitability, insomnia, anxiety,
- Nausea, vomiting, abdominal pain, diarrhea, constipation, bloating,
- Fatigability, general weakness,
- Patients with severe allergies should fear anaphylactic shock,
- A temporary decrease in the concentration of testosterone in the blood plasma (normalized 24 hours after admission). Nevertheless, this fact can cause a violation of the menstrual cycle in women, gynecomastia and erectile dysfunction in men, although this is highly unlikely.
Pharmacokinetics
With external application and with the introduction of suppositories, ketoconazole is practically not absorbed. But when used in the form of tablets is very well absorbed. Cmax is achieved after 2 hours. It binds to proteins, erythrocytes. Is able to penetrate into the cerebrospinal fluid. For 96 hours, 70% of the amount of ketoconazole taken with urine and through the digestive tract is excreted.
Other
Shelf life 3 years, at a temperature of no more than 30 ° C. Sold by prescription.
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* - The average value among several sellers at the time of monitoring is not a public offer
1 comment
I am ashamed.