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Instructions for use
The ointment is made on the basis of petrolatum and is absorbed longer than the cream and lasts longer, but oily skin may be inappropriate.
The action of the cream has a wide range and is aimed at almost all known pathogenic fungi, as well as bacteria that cause infectious diseases in humans. These include dermatophytes, dimorphic fungi, blastomycosis, mold fungi, yeast, protozoa, some types of gram-positive cocci, corynebacteria, and the cream has a trichonomacid action.
The effect of Clotrimazole Cream is aimed at slowing the growth of microorganisms. With a small concentration of the cream has a fungistatic effect inhibiting the growth of fungi, and in large, has a fungicidal effect causing irreparable damage to fungal cells damaging the membrane, which is the cause of their complete death.
Also, the ointment leads to disruption of the processes important for the vital activity of organisms, destroying the components of the cellular structure: proteins, polysaccharides, fats, amino acids. The cream interacts with fungal cell enzymes, increasing the concentration of hydrogen peroxide to a toxic level, which also leads to their death.
Species of fungi resistant to the drug are practically not found, there is data only for some strains of Candida fungi. Information about the development of resistance to fungi sensitive to clotrimazole has not been reported.
Cream and ointment Clotrimazole is used for fungal infections of the skin and mucous membranes of drug-resistant fungi.
- fungal diseases of skin folds, feet, hands, torso, groin ;
- pityriasus lichen;
- multi-colored lichen;
- candidal vulvitis and vulvovaginitis ;
- fungal infections of the outer ear .
Allergic reactions or hypersensitivity to the active substance of the drug or to its other components, the menstrual period (with vaginal application). It is not recommended to apply the cream in the first trimester of pregnancy and during lactation.
Dosing and Administration
Clotrimazole is used for external use, it is applied to pre-cleaned and dried affected areas of the body with slightly massaging movements 2-3 times a day. For one application, depending on the area of the site, use a small amount of cream, usually a column with a length of 5 mm.
The duration of treatment is prescribed individually, it depends on the strain of the fungus, the severity of the disease and the effectiveness of therapy. On average, treatment lasts about 4 weeks. An important addition: after the disappearance of all manifestations of the disease, it is necessary to use the drug for another 1-2 weeks, this will help to avoid relapses.
Dermatomycosis should be treated for 3-4 weeks, lichen-colored lichen for 1-3 weeks, candidal vulvitis for 1-2 weeks, erythrasma for 2-4 weeks.
Vaginally, cream portion of 5 g is introduced deep into the vagina 1 time per day, for 3 days. For balanitis or candidal vulvitis, the cream is applied more often and longer - 2-3 times a day, for 1-2 weeks. Also during treatment you can apply the cream on the external genital organs, to enhance the effect. When the disease recurs, the course can be repeated.
Of the side effects there may be local reactions to the components of the cream, such as itching, rashes, peeling of the skin, swelling, burning, blisters. Also not excluded allergic reactions to the drug: urticaria, pruritus.
The use of large doses of the drug externally does not cause any negative reactions and life-threatening conditions.
When taking the cream inside can cause headache and dizziness, nausea, vomiting. In this case, the patient’s symptoms should be treated.
Ointment or cream Clotrimazole should not be applied to the skin around the eyes, in order to avoid contact with eyes.
If allergic reactions or symptoms of sensitivity to the drug appear, its use should be discontinued.
If after 4 weeks of treatment the effect was not observed, it is necessary to confirm the accuracy of the diagnosis.
In the treatment of genital fungal infections, it is necessary to use the drug in both partners, it will protect against reinfection.
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