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Instructions for use
"Orungamin" is an antifungal agent based on itraconazole. The drug is effective against fungi of various kinds, therefore it is often prescribed to patients when diagnosing fungal infections in them (candidiasis, mycoses, etc.).
High efficiency and good portability fully justify the high cost.
When is it used?
"Orungamin" is prescribed to patients with fungal lesions of varying intensity, including infections of the genital tract and internal organs (for example, rare candidiasis of the intestine or esophagus). High performance allows you to use the drug in the absence of a therapeutic effect of therapy by other means.
As indications for the appointment, the manufacturer indicates:
- fungal infections of the mucous membranes (including organs of vision);
- fungal infections of the skin and nails;
- candidiasis of the oral cavity , internal organs (for example, the esophagus );
- genital candidiasis ;
- systemic mycoses;
- systemic aspergillosis;
- scaby ;
- damage to the nail plate moldy, yeast-like fungi and dermatophytes;
- cryptococcal meningitis;
How to use?
"Orungamin" at a dosage of 200 mg is administered once a day with the following diagnoses (the duration of treatment is indicated in parentheses):
- vulvar and vaginal candidiasis (3 days);
- fungal keratitis (3 weeks);
- fungal dermatitis of smooth skin (1 week);
- pityriasis versicolor (1 week);
- aspergillosis (from 2 to 5 months);
- cryptococcosis without symptoms of meningitis (up to 1 year);
- chromomycosis (half a year);
- histoplasmosis (8 months).
"Orungamin" at a dosage of 200 mg is prescribed 2 times a knock with the following diagnoses (the duration of treatment is indicated in parentheses):
- cryptococcal meningitis (up to 12 months);
- histoplasmosis (8 months);
- blastomycosis (half a year);
- vulvovaginal candidiasis (1 day).
"Orungamin" at a dosage of 100 mg is prescribed 1-2 times a day for the following diseases (the approximate duration of therapy is shown in parentheses):
- ringworm (15 days);
- oral candidiasis (15 days);
- candidiasis (from 3 weeks to 7 months);
- sporotrichosis (3 months);
- paracoccidioidomycosis (half a year);
- blastomycosis (half a year);
- chromomycosis (half a year).
Treatment of fungal lesions of the nail plates (onychomycosis) is conducted by courses prescribed by the attending physician.
Relative contraindications for the appointment of "Orungamin" are the children's age, pregnancy and lactation, severe diseases of the liver and kidneys against the background of their partial dysfunction.
As an absolute limitation, the manufacturer indicates intolerance to the components of the drug, as well as taking certain medications, including:
- HMG-CoA reductase inhibitors (for example, Simvastatin);
- preparations with active substances, for the metabolism of which the participation of CYP3A4 enzymes is necessary (for example, Pimozide, Midazolam, Tsizaprid, etc.).
Pregnancy and lactation
The use of "Orungamin" during pregnancy is possible only for extreme indications, which include systemic mycoses that threaten the patient's life. Studies of the drug regarding the safety of use for any period of gestation were not conducted.
Important! Women with preserved reproductive function should use contraceptive methods for the entire period of treatment using Orungamin. If conception occurs against the background of the drug. The occurrence of defects and malformations in the embryo and fetus cannot be ruled out.
Itraconazole penetrates into breast milk in insignificant concentrations, so use during lactation requires the advice of a doctor (including a pediatrician, an observing child).
No cases of overdose have been reported. In case of accidental ingestion of high doses of the drug, symptomatic treatment is indicated, including gastric lavage and the administration of sorbents (for example, activated carbon).
The most common side effects when taking Orungamin are from the digestive tract and the nervous system. This is manifested by increased tension, nervous irritability, headaches, and digestive disorders. The patient may experience daily nausea, in some cases vomiting is possible.
Other negative manifestations are less common, for example:
- cycle failures in women, delayed menstruation;
- edema, dropsy of internal organs;
- skin reactions (rash, itching, eczema, prickly heat, etc.);
- heart failure;
- Stevens-Johnson syndrome.
Any negative reactions are a reason for seeking medical attention.
Composition and dosage form
Orungamin is available in the form of pink gelatin capsules with a blue cap with yellow granules. Capsules are placed in contour cells of 5 and 15 pieces (in a package 1 cell of 5 or 15 pieces, or 3 cells of 5 pieces).
One capsule contains 100 mg of itraconazole.
The half-life of itraconazole lasts from 24 to 36 hours. Metabolites are excreted in the urine (the main part) and feces (a small amount). The maximum concentration in blood plasma is reached in 3-4 hours after administration.
The drug should be stored no more than 3 years within the shelf life at a temperature of from 10 to 25 degrees.
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