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Other antivirals and immunomodulators


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Instructions for use

Packaging, blister and instructions on the table Valtrex is an antiviral agent prescribed for various herpetic infections .

The therapeutic effect is achieved by converting the active substance of the drug (valacyclovir) to another substance (acyclovir) as a result of reaction with the enzyme varacyclovir hydrolase produced by the liver.

The main function of acyclovir is the inhibition of the synthesis of the DNA of the herpes viruses.

Indications for use

Valtrex can be used to prevent the recurrence of skin infections triggered by any varieties of herpes simplex, as well as to prevent transplant rejection during organ transplants caused by cytomegalovirus infections. Statistical studies confirm a decrease in the probability of transmission of genital herpes virus from an infected partner to a healthy one with suppressive (prophylactic) therapy with Valtrex.

Dosage and administration

valtrex-6 The drug is administered orally, without reference to food intake. Tablets should be taken with a small amount of water. For children over 12 years old, Valtrex is prescribed only for the prevention of cytomegalovirus infections and transplant rejection during organ transplantation. For other indications, the drug is intended only for adults.

  • In the treatment of genital and labial herpes: 500 mg of the drug 2 times a day for 5 days. With advanced forms of the disease, the duration of therapy can be extended to 10 days.
  • When treating herpes zoster: 1000 mg 3 times a day. Therapeutic course - 7 days.
  • When suppressive therapy (prevention of recurrent infection of HSV): 500 mg 1 time per day. The duration of admission is determined by the attending physician.
  • For the prevention of transmission of the virus of genital herpes from an infected partner to a healthy one: 500 mg once a day. Therapeutic course - 12 months.
  • For the prevention of CMV infections in adults and children over 12 years old: 2 g. 4 times a day. The dosage is adjusted depending on the indicators of creatinine clearance.


Hypersensitivity to acyclovir and other components of the drug.

With extreme caution, the agent is prescribed to patients with:

  • HIV infection in a clinically pronounced course;
  • renal failure;
  • undergoing a parallel course of treatment with nephrotoxic drugs.

Pregnancy and lactation

English Due to the lack of data on the effects of Valtrex on the body during gestation, it is prescribed to pregnant women only in extreme cases when the potential benefits of the drug are higher than the potential risk to the child.

In unchanged form, valacyclovir is not detected in breast milk or the urine of a newborn. Therefore, it can be prescribed for the treatment of herpes infections during lactation, but with caution.


Side effects with a one-time excess of a therapeutic dose of the drug are not fixed. Regular overdosing is fraught with the following phenomena:

  • headaches;
  • nausea with vomiting;
  • inhibition of thinking.

Side effects

From the side of the central nervous system possible headaches, dizziness, inhibited thinking. In patients with renal insufficiency, in exceptional cases, encephalopathy, convulsions, and coma may develop.

In rare cases, the organs of the gastrointestinal tract can respond to valaciclovir with vomiting, diarrhea, increased gas formation, skin with itching and rashes, and blood circulation with leukopenia and thrombocytopenia. Renal function disorders, including acute renal failure, are very rarely diagnosed on the part of the excretory system.

Composition and pharmacokinetics

tablet size 1 tablet of the drug contains 556 mg of the active component valacyclovir hydrochloride. This amount is equivalent to 1 therapeutic dose (500 mg) of varaciclovir. Additional components are:

  • microcrystalline cellulose;
  • magnesium stearate;
  • Povidone;
  • crospovidone;
  • silica.

The active component is absorbed from the gastrointestinal tract, converting to acyclovir and valine under the influence of the hepatic enzyme valacycovirhydralase. Acyclovir is excreted in the urine.

The half-life of acyclovir from blood plasma is about 3 hours (in patients with normal renal function) and about 14 hours in patients with renal insufficiency.

Shelf life and storage conditions

The drug should be stored away from direct sunlight at t not higher than 30 ° C. Valtrex's shelf life is 3 years from the date of issue.


(Leave your feedback in the comments)

Herpes on the lip bothers me with an enviable periodicity: once every one and a half to two years. I tried and Acyclovir, and Zovirax, and some other ointment, the names of which I do not remember, but to no avail. And now the herpes came to me once again while on holiday abroad. The pharmacy pharmacist in broken English said that they all are treated with Valtrex. I decided to try. On the first day I drank as many as 3 tablets (for sure!), And in the following days, as expected, two each. Two days later, herpes was blown away, leaving a small spot, and after a week it was gone. The side effects described in the instructions may not faintly frighten, but nothing like this has manifested to me. Now, if the herpes decides to visit me again, I have Valtrex for him. Julia, 28 years old

For me, Valtrex is the best remedy for herpes. I tried to replace it with cheaper medicines - the effect is not the same. But now I know that I will not waste my money. Acne on the lip is already on the third or fourth day, despite the fact that Metrogil did not take them for a week before. Angelina, 40 years old
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These pills helped me even run herpes win. I had never encountered this filth before, and when something puffed up on my lip, I thought it was a pimple. Well, it became my habit to treat it with metrogyle and instead of one pimple I received several bubbles. In time, a friend came to visit me and immediately diagnosed herpes. And she advised Valtrex. I added acyclovir to the pills (I also bought it at the pharmacy), and these two remedies quickly relieved me of herpes. Lyudmila, Saratov

By and large, herpes is easier to prevent than to cure. But if prevention has failed, it is necessary to be treated. I tried Valtrex on myself and the experience was successful: the inflammation subsides, and after taking the course I forget about herpes for a long time. By the way, it is not always possible to find it in city pharmacies, so I order it via the Internet. The price is normal, it is consistent with the quality of the drug. The main thing is to save herpes! Vitaly, Murmansk

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