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Instructions for use
Chlorhexidine digluconate is an antiseptic. At a concentration of 0.05%, it has a bacteriostatic effect on gram-positive and gram-negative bacteria. When exposed to 10 minutes effective against fungi of the genus Candida, dermatophytes and trichophyton. At a concentration of 0.1% kills viruses.
Available in the form of a solution for external use in glass and polymer bottles with a volume of 100 ml. It looks like a liquid with no color or a slightly yellowish, odorless.
Chlorhexidine solution is used for:
- treatment and prevention of diseases, the development of which occurs under the action of microorganisms sensitive to the drug;
- sterilization of medical instruments at a temperature of +70 degrees;
- treatment of injuries of the skin and mucous membranes (infected wounds, burns, etc.).
Dosage and administration
To prevent infection as a result of unprotected intercourse, chlorhexidine 0.05% solution is used within two hours after contact. Men are given 2-3 ml of the drug in the urethra, and women - 1-2 ml in the urethra and vagina. Additionally, the solution is carried out treatment of the skin on the pubis, genitals and inner thighs. To maximize the effectiveness of the drug, for two hours after its introduction should refrain from urinating.
Remember that unlike Miramistin, Chlorhexidine at a concentration of 0.05% does not have sufficient antiviral activity and is not able to protect against certain diseases, similarity here .
In urethritis, urethroprostatitis and other inflammatory processes in the urinary tract, 2-3 ml of chlorhexidine digluconate 0.05% is injected into the urinary canal 1-2 times a day. The drug is used for 10 days every other day.
Perhaps gargling, detailed instructions here .
For the prevention of infection after dental operations and operations on the ENT organs, chlorhexidine solution 0.05% is used for rinsing and irrigation 2-3 times a day.
For treatment of damaged areas of the skin, including wounds and burns, with the help of the drug irrigation and application are carried out 2-3 times a day. Applications impose on 1-2 minutes.
To dilute 20% chlorhexidine digluconate to a concentration of 0.05%, take 2.5 ml of the concentrated solution and top up with distilled or sterile water for injection to the 1 liter mark.
Self-preparation of the solution is possible only under aseptic conditions. Aqueous solutions must be sterilized for half an hour at a temperature of 116 degrees. Sterilization using ionizing radiation is prohibited.
Chlorhexidine 0.05% can not be used:
- for the treatment of patients with dermatitis;
- for disinfection after operations on the central nervous system and the auditory canal;
- for the treatment of ophthalmic diseases;
- simultaneously with other antiseptics.
With caution, the drug is used in children.
Pregnancy and lactation
Chlorhexidine digluconate can be prescribed to pregnant and lactating women. It is established that the drug does not affect the health of the unborn child. However, to eliminate all risks, only short-term use of an antiseptic solution during pregnancy and breastfeeding periods is allowed.
If the instructions are followed, an overdose of chlorhexidine is excluded. If a person accidentally swallows the drug, you should immediately wash the stomach, using milk, raw egg, gelatin or soap.
Sometimes as a result of the use of chlorhexidine digluconate 0.05%, patients develop the following side effects from the skin:
- dry skin
With prolonged rinsing and irrigation of the mouth with chlorhexidine are possible:
- discoloration of tooth enamel;
- taste disorder;
- the appearance of tartar.
There is no specific antidote for chlorhexidine. If there are side effects, symptomatic treatment is carried out.
Composition and pharmacokinetics
In 1 l of a solution of the drug in a concentration of 0.05% contains 0.5 mg of chlorhexidine bigluconate and up to 1000 ml of distilled or sterile water for injection.
The drug is practically not absorbed from the gastrointestinal tract. If 300 mg of chlorhexidine is accidentally swallowed, the peak concentration of a substance in the blood plasma is reached in half an hour, it is 0.206 μg / l. Up to 90% of the drug is excreted by the intestine along with feces, less than 1% excrete the kidneys through urine.
Interaction with other substances
Chlorhexidine digluconate is used in a neutral environment. At pH over 8 forms a precipitate. In hard water, bactericidal effect is reduced.
The drug is pharmaceutically incompatible with alkalis, soap, as well as colloids, gum arabic, carboxymethyl cellulose and other anionic compounds. Not recommended for simultaneous use with iodine.
Chlorhexidine solution is compatible with cationic drugs - bromide, benzalkonium chloride.
Under the influence of ethyl alcohol, the effectiveness of the drug increases.
With open head injuries, spinal cord injuries and perforation of the eardrum, chlorhexidine should not be allowed to enter the surface of the brain and its membranes, as well as into the inner ear.
If the drug gets on the mucous eyes, they should be thoroughly rinsed with clean water.
The higher the temperature, the more intense the drug becomes. However, at +100 degrees its partial decomposition occurs.
If the drug gets on the fabric, then bleaching on it may appear brown spots.
The shelf life of the drug in the original packaging - 2 years. The solution, prepared personally, is valid for 1 week.
Store the drug should be at a temperature of +1 to +25 degrees, protecting from contact with direct sunlight.
Dispensing pharmacies without a prescription.
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